コデインそのものはμ-オピオイド受容体に弱い親和力を示す。主要な鎮痛作用はμ-オピオイド受容体へのモルヒネの親和性による。しかし他の作用または副作用は他のオピオイド受容体への作用による。

Breastfeeding. Usually do not consider promethazine/phenylephrine/codeine while you're breastfeeding. Promethazine/phenylephrine/codeine can go into breast milk. Convey to your Health care service provider If you're breastfeeding or plan to breastfeed.

Like other opioids, codeine use carries a risk of overdose and poisoning if you consume a lot more than proposed. Signs of overdose involve:

These signs or symptoms may suggest that you will be an "ultra-rapid metabolizer of codeine". As a result, there may be an excessive amount morphine in the body and more Negative effects from morphine than standard. Children might be Specially sensitive to this impact. Don't give this drugs to:

Codeine: A analyze in rats and rabbits reported no teratogenic influence of codeine administered throughout the period of organogenesis in doses ranging from five to one hundred twenty mg/kg. While in the rat, doses in the 120mg/ kg stage, during the toxic array to the Grownup animal, ended up linked to a rise in embryo resorption at some time of implantation.

Using narcotics for some time could potentially cause severe constipation. To forestall this, your medical doctor could immediate you to get laxatives, consume loads of fluids, or improve the amount of fiber as part of your food plan.

on the codeine drug label cautioning against prescribing codeine to kids of any age to deal with soreness soon after operation to remove tonsils or adenoids. We also issued Drug Basic safety Communications in July 2015 and September 2015 more info warning about the chance of major respiration troubles in some youngsters who metabolized codeine and tramadol much faster to their active type than common (termed ultra-quick metabolism), creating most likely dangerously high degrees within their bodies way too quickly.

Epinephrine – Because of the likely for promethazine to reverse epinephrine’s vasopressor effect, epinephrine shouldn't be used to take care of hypotension associated with promethazine overdose.

It's important you get rid of undesirable opioid medicines securely. Unused medicines could be returned to any pharmacy. Do not hold unused codeine 'just in the event'. This can cause risky or inappropriate use.

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Breathing Challenges. Promethazine/phenylephrine/codeine might induce slow or shallow respiratory, particularly when you may have respiration challenges from A different condition or choose other medicines that could gradual your respiration.

Inquiring regarding your treatment or medicine is significant that will help you fully grasp your options. Here is a guide to thoughts it is best to request your pharmacist or health practitioner just before taking any medication.

This drugs may well cause some individuals to be dizzy, drowsy, or considerably less notify than they are Usually. Will not travel or do anything which could be perilous until finally you understand how this drugs impacts you.

Postmarketing circumstances of respiratory despair, including fatalities, have already been noted with use of promethazine hydrochloride in pediatric individuals less than two a long time of age. A variety of excess weight-based doses of promethazine hydrochloride have resulted in respiratory depression in these patients.